MOTS-C

MOTS-C, also published as MOTSc, is catalogued here as: Mitochondrial-derived 16-amino-acid peptide. Studied in cells and mice for communication between mitochondria, metabolic pathways and the cell nucleus. A mitochondria-derived peptide studied in the lab for how cells regulate metabolism and respond to stress.

Cells / animal literature: The 2015 study linked MOTS-c to AMPK-related cellular signalling and reported altered insulin-resistance outcomes in mouse models. Cells and mice, not a human efficacy trial or an energy/weight-loss claim for PLP material.

Cells literature: The 2018 study reported nuclear translocation during metabolic stress and changes in stress-responsive gene regulation. Mechanistic experiments do not establish a treatment outcome in people.

When comparing published work, match the exact molecular identity, salt form and strength to the paper. Findings in cell or animal models describe those models only and do not establish outcomes in people. The reconstitution calculator converts vial content and diluent volume into concentration for laboratory preparation.

Proof Line Peptides lists MOTS-C as a vial in 40 mg and 10 mg, with pack sizes of 1, 3, 5 and 10. Prices are shown in Canadian dollars, and orders ship from Toronto by tracked Canadian service.

The matched PPB Analytical Inc. report for MOTS-C 40 mg (report 2026030620-02, dated Mar. 27, 2026) records 98.27% purity. It documents the supplier sample sent for testing, not every shipped lot, and the original PDF is linked on this page.

Shipped lyophilized (freeze-dried) and stable at room temperature in transit. Store sealed vials in the fridge or freezer on arrival. Once reconstituted, refrigerate. Anything not right? Our guarantee covers it.