What is PT-141?
PT-141 is bremelanotide, described as a melanocortin receptor agonist. An approved United States formulation exists with specific labelling; this listing is laboratory research material and is not that product.
Key concepts: Receptor · Agonist · Endpoint
How it works and what researchers study
Research in this area examines melanocortin receptor signalling and sexual-desire endpoints in defined populations. Labelling for the approved formulation also documents adverse reactions and precautions.
What the evidence shows
United States labelling covers acquired, generalized hypoactive sexual desire disorder in premenopausal women, with stated exclusions, and notes that the mechanism for that indication is not fully known. Transient blood-pressure increases, nausea and hyperpigmentation are described among relevant considerations.
Limits of the evidence
- The approved indication does not extend to men, to postmenopausal women, or to performance enhancement.
- The mechanism for the labelled indication is described as not fully established, so precise pathway claims go beyond the source.
- United States labelling implies nothing about Canadian authorization, and describes the approved formulation rather than this research vial.
References
- Official United States prescribing information for bremelanotide injection (Vyleesi), revised March 2024. United States labelling only. View source
- Health Canada. Drug Product Database: the official list of drug products authorized for sale in Canada. View source





