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CJC-1295 and ipamorelin: two separate signals in one blend listing

By Proof Line Peptides · Published · 3 min read

This listing names two research compounds that act through different mechanisms on the growth-hormone axis. The published studies examined them separately, so component evidence is all the cited literature supports — not a combined effect, and not a specific ratio.

Two distinct signals

CJC-1295 is discussed as a long-acting analogue of growth-hormone-releasing hormone. Two short randomized controlled studies in healthy adults reported prolonged stimulation of growth hormone and IGF-I secretion with long-acting CJC-1295 given alone. [Teichman et al., 2006]

Ipamorelin is a pentapeptide described as a selective growth hormone secretagogue, studied in cell preparations, rats and swine with receptor pharmacology resembling that of growth-hormone-releasing peptides. It is therefore a different entry point to the same axis, not a duplicate of the first. [Raun et al., 1998]

What the blend listing does not specify

Component ratioThe catalogue lists a 10 mg blend. How that is divided between components is not stated, so it is unknown.
DAC statusWhether the CJC-1295 component is the DAC (long-acting) form or a non-DAC form is supplier-specified and not stated here.
Half-life figuresPublished long-acting pharmacology cannot be quoted as a specification for this vial.

What has not been shown

The cited studies do not demonstrate synergy between the two components, and they do not report sleep, muscle or anti-ageing outcomes. Claims of that kind would require trials designed around those endpoints in a defined population. [Teichman et al., 2006][Raun et al., 1998]

Checklist for blend comparisons

  1. Write down each component name exactly as listed.
  2. Mark ratio and molecular form as “not stated” unless documented.
  3. Keep each component’s literature attached to that component.
  4. Do not transfer a long-acting half-life figure onto an unspecified form.

CJC-1295 with and without DAC: a naming distinction, not a detail

Short answer: “CJC-1295” is used online for two different things — a GHRH analogue carrying a Drug Affinity Complex (DAC) that extends its persistence, and the same peptide backbone without that modification. The published long-acting pharmacokinetic work is about the DAC-bearing form and does not transfer to a non-DAC product. [Teichman et al., 2006]

With DACThe form studied in the published single-dose work on a long-acting GHRH analogue. Its reported persistence is a property of that modified molecule.
Without DAC (often written “mod GRF 1-29”)The unmodified backbone. Persistence findings from the DAC literature are not evidence about it.
What a listing name settlesNothing on its own. “CJC-1295” without a stated modification leaves the question open.
Which form this listing isUnknown to us in writing. We do not have a supplier statement specifying DAC or non-DAC, so we do not claim either, and we do not apply the long-acting findings to this listing.

Component evidence versus blend evidence

A blend adds a second gap. Published work on each component separately is evidence about that component at the doses and conditions studied. It is not evidence about a combination, and the ratio in a blend changes what is present. Where no ratio is documented, the honest statement is that the per-component quantities are unknown — not an estimate.

Frequently asked

Is the 10 mg split 5 mg and 5 mg?
That is not stated, so it should not be assumed. Component allocation is only known when the listing or supplier documentation specifies it.
Do CJC-1295 and ipamorelin work the same way?
No. One is described as a growth-hormone-releasing hormone analogue; the other as a selective growth hormone secretagogue. They are distinct signals studied separately.
Does combining them produce better results?
The cited studies do not establish that. Synergy is a specific empirical claim that would need research on the combination itself.

References

  1. Teichman SL et al. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab. 2006. doi:10.1210/jc.2005-1536 View source
  2. Raun K et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998. doi:10.1530/eje.0.1390552 View source
CJC-1295 + Ipamorelin vial render

Compound in the catalogue

CJC-1295 + Ipamorelin

10 mg blend · $69.99 CAD · for laboratory research use only

View compound details